Ultrasonic Assisted-Reflux Synergistic Extraction of Camptothecin and Betulinic Acid from Camptotheca acuminata Decne. Fruits

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Ultrasonic Assisted-Reflux Synergistic Extraction of Camptothecin and Betulinic Acid from Camptotheca acuminata Decne. Fruits.

A novel and efficient ultrasonic assisted-reflux synergistic extraction (UARSE) method for extracting camptothecin (CPT) and betulinic acid (BA) from Camptotheca acuminata Decne. fruits has been developed in this study. The advantages of the ultrasonic and reflux extraction methods have been combined in the UARSE method and used to extract CPT and BA for the first time. The parameters influenci...

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Cellular localisation of the anti-cancer drug camptothecin in Camptotheca acuminata Decne (Nyssaceae).

In Camptotheca acuminata, we studied the cellular sites of accumulation of the alkaloid camptothecin (CPT), in both plants grown in the field and those grown in a greenhouse, subjecting the latter to stress (i.e., draught, nutritional deficit, and pruning). Fresh sections of the leaf, stem, and root were analysed for the presence of CPT by examining the autofluorescence that the CPT molecule em...

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Development of an Ionic Liquid-Based Ultrasonic/Microwave-Assisted Simultaneous Distillation and Extraction Method for Separation of Camptothecin, 10-Hydroxycamptothecin, Vincoside-Lactam, and Essential Oils from the Fruits of Camptotheca acuminata Decne

An ionic liquid-based ultrasonic/microwave-assisted simultaneous distillation and extraction (IL-UMASDE) method for isolating camptothecin (CPT), 10-hydroxycamptothecin (HCPT), vincoside-lactam (VCS-LT), and essential oils (EOs) from Camptotheca acuminata Decne fruits was developed. The important parameters were optimized using single-factor and central composite design experiments. The optimum...

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Variation in camptothecin content in Camptotheca acuminata leaves

Variations in camptothecin (CPT) content in relation to leaf characteristics namely leaf area, leaf biomass, and specific leaf area (leaf area divided by leaf biomass), and the influence of climatic factors on CPT content in saplings of Camptotheca acuminata Decne. were studied. Leaf area and CPT content showed a logarithmic relationship in young leaves similar to that between leaf biomass and ...

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Antifungal activity of camptothecin, trifolin, and hyperoside isolated from Camptotheca acuminata.

Leaf spots and root rots are major fungal diseases in Camptotheca acuminata that limit cultivation of the plant for camptothecin (CPT), a promising anticancer and antiviral alkaloid. Bioassays showed that pure CPT and flavonoids (trifolin and hyperoside) isolated from Camptotheca effectively control fungal pathogens in vitro, including Alternaria alternata, Epicoccum nigrum, Pestalotia guepinii...

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ژورنال

عنوان ژورنال: Molecules

سال: 2017

ISSN: 1420-3049

DOI: 10.3390/molecules22071076